我国于20世纪90年代初期开始推广烟嘧磺隆，作为一种高效、广谱的磺酰脲类除草剂，大量应用于玉米苗后的杂草防治。多年生产实践发现，烟嘧磺隆会对部分玉米品种产生一定药害，从而造成玉米产量下降。挖掘并应用玉米抗烟嘧磺隆基因，培育抗除草剂新品种，是解决药害问题的最有效办法。本文概述了烟嘧磺隆的除草、选择及解毒机制，不同玉米品种对烟嘧磺隆抗性差异，重点对玉米抗烟嘧磺隆基因的遗传机制、基因定位和克隆以及不同单倍型等进展进行了系统阐述，以期加快抗性基因的应用进程，推进抗除草剂新品种的培育，保障我国玉米生产安全。

Nicosulfuron was widely applied in China since early 1990s, which was used as an efficient, broad-sulfonylurea maize herbicide at seedling stage. However, recent reports showing that nicosulfuron was genotype dependent–it causes serious injuries to some maize varieties, which can result in a reduction of maize grain yield. The most effective way to solve the problem is to discover and apply the resistance gene of nicosulfuron in maize, which could cultivate new varieties of herbicide resistance. In this review, we expound the development of the the weed control, selection, detoxification mechanism and the resistance differences of different maize varieties to nicosulfuron. Meanwhile, we focus on systematic summary and explanation of the progress of genetic mechanism, gene localization, cloning and different haplotypes of resistance to nicosulfuron in maize. That will help us accelerate the process of the application of resistance genes and the herbicide resistance varieties breeding, which would ensure the safety of corn production in China.

本研究由国家自然科学基金青年[31601320]和泰山产业英才（高效生态农业产业创新类）资助。